作者
Amy M Padula, Xuejuan Ning, Shivani Bakre, Emily S Barrett, Tracy Bastain, Deborah H Bennett, Michael S Bloom, Carrie V Breton, Anne L Dunlop, Stephanie M Eick, Assiamira Ferrara, Abby Fleisch, Sarah Geiger, Dana E Goin, Kurunthachalam Kannan, Margaret R Karagas, Susan Korrick, John D Meeker, Rachel Morello-Frosch, Thomas G O’Connor, Emily Oken, Morgan Robinson, Megan E Romano, Susan L Schantz, Rebecca J Schmidt, Anne P Starling, Yeyi Zhu, Ghassan B Hamra, Tracey J Woodruff, program collaborators for Environmental influences on Child Health Outcomes
发表日期
2023/3/15
期刊
Environmental health perspectives
卷号
131
期号
3
页码范围
037006
简介
Background
Per- and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous chemicals associated with risk of adverse birth outcomes. Results of previous studies have been inconsistent. Associations between PFAS and birth outcomes may be affected by psychosocial stress.
Objectives
We estimated risk of adverse birth outcomes in relation to prenatal PFAS concentrations and evaluate whether maternal stress modifies those relationships.
Methods
We included 3,339 participants from 11 prospective prenatal cohorts in the Environmental influences on the Child Health Outcomes (ECHO) program to estimate the associations of five PFAS and birth outcomes. We stratified by perceived stress scale scores to examine effect modification and used Bayesian Weighted Sums to estimate mixtures of PFAS.
Results
We observed reduced birth size with increased concentrations of all PFAS. For a 1-unit higher log-normalized exposure to perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid …
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AM Padula, X Ning, S Bakre, ES Barrett, T Bastain… - Environmental health perspectives, 2023