作者
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea Mcfarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O’Toole, Shi-xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
发表日期
2015/12
期刊
Breast Cancer Research
卷号
17
页码范围
1-18
出版商
BioMed Central
简介
Introduction
The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged.
Methods
microRNA profiling was conducted on stromal and epithelial cellular subsets microdissected from the pubertal mouse mammary gland. miR-184 was reactivated by transient or stable overexpression in breast cancer cell lines and examined using a series of in vitro (proliferation, tumour-sphere and protein synthesis) assays. Orthotopic xenografts of breast cancer cells were used to assess the effect of miR-184 on tumourigenesis as well as distant …
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YW Phua, A Nguyen, DL Roden, B Elsworth, N Deng… - Breast Cancer Research, 2015