作者
Dor Zaguri, Shira Shaham-Niv, Priyadarshi Chakraborty, Zohar Arnon, Pandeeswar Makam, Santu Bera, Sigal Rencus-Lazar, Paul R Stoddart, Ehud Gazit, Nicholas P Reynolds
发表日期
2020/4/20
期刊
ACS applied materials & interfaces
卷号
12
期号
19
页码范围
21992-22001
出版商
American Chemical Society
简介
Phenylalanine was the minimalistic and first of numerous nonproteinaceous building blocks to be demonstrated to form amyloid-like fibrils. This unexpected organization of such a simple building block into canonical architecture, which was previously observed only with proteins and peptides, has numerous implications for medicine and supramolecular chemistry. However, the morphology of phenylalanine fibrils and their mechanical properties was never characterized in solutions. Here, using electron and atomic force microscopy, we analyze the morphological and mechanical properties of phenylalanine fibrils in both air and fluids. The fibrils demonstrate an exceptionally high Young’s modulus (up to 30 GPa) and are found to be composed of intertwined protofilaments in a helical or twisted ribbon morphology. In addition, X-ray scattering experiments provide convincing evidence of an amyloidal cross-β-like …
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D Zaguri, S Shaham-Niv, P Chakraborty, Z Arnon… - ACS applied materials & interfaces, 2020