查看文章

Supramolecular polymer coassembly is a useful approach to modulate peptide nanostructures. However, the coassembly scenario where one of the peptide building blocks simultaneously forms a hydrogel is yet to be studied. Herein, we investigate the coassembly formation of diphenylalanine (FF), and Fmocdiphenylalanine (FmocFF) within the 3D network of FmocFF hydrogel. The overlapping peptide sequence between the two building blocks leads to their coassembly within the gel state modulating the nature of the FF crystals. We observe the formation of branched microcrystalline aggregates with an atypical curvature, in contrast to the FF assemblies obtained from aqueous solution. Optical microscopy reveal the sigmoidal kinetic growth profile of these aggregates. Microfluidics and ToFSIMS experiments exhibit the presence of coassembled structures of FF and FmocFF in the crystalline aggregates …