作者
Mehdi Tafti, Gert J Lammers, Yves Dauvilliers, Sebastiaan Overeem, Geert Mayer, Jacek Nowak, Corinne Pfister, Valérie Dubois, Jean-François Eliaou, Hans-Peter Eberhard, Roland Liblau, Aleksandra Wierzbicka, Peter Geisler, Claudio L Bassetti, Johannes Mathis, Michel Lecendreux, Ramin Khatami, Raphaël Heinzer, José Haba-Rubio, Eva Feketeova, Christian R Baumann, Zoltán Kutalik, Jean-Marie Tiercy
发表日期
2016/3/1
期刊
Sleep
卷号
39
期号
3
页码范围
581-587
出版商
Oxford University Press
简介
Study Objectives
Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no evidence for CD4+ T-cell-mediated mechanism in narcolepsy. Since neurons express class I and not class II molecules, the final effector immune cells involved might include class I-restricted CD8+ T-cells.
Methods
HLA class I (A, B, and C) and II (DQB1) genotypes were analyzed in 944 European narcolepsy with cataplexy patients and in 4,043 control subjects matched by country of origin. All patients and controls were DQB1*06:02 positive and class I associations …
学术搜索中的文章
M Tafti, GJ Lammers, Y Dauvilliers, S Overeem… - Sleep, 2016