作者
Fernando Althabe, José M Belizán, Elizabeth M McClure, Jennifer Hemingway-Foday, Mabel Berrueta, Agustina Mazzoni, Alvaro Ciganda, Shivaprasad S Goudar, Bhalachandra S Kodkany, Niranjana S Mahantshetti, Sangappa M Dhaded, Geetanjali M Katageri, Mrityunjay C Metgud, Anjali M Joshi, Mrutyunjaya B Bellad, Narayan V Honnungar, Richard J Derman, Sarah Saleem, Omrana Pasha, Sumera Ali, Farid Hasnain, Robert L Goldenberg, Fabian Esamai, Paul Nyongesa, Silas Ayunga, Edward A Liechty, Ana L Garces, Lester Figueroa, K Michael Hambidge, Nancy F Krebs, Archana Patel, Anjali Bhandarkar, Manjushri Waikar, Patricia L Hibberd, Elwyn Chomba, Waldemar A Carlo, Angel Mwiche, Melody Chiwila, Albert Manasyan, Sayury Pineda, Sreelatha Meleth, Vanessa Thorsten, Kristen Stolka, Dennis D Wallace, Marion Koso-Thomas, Alan H Jobe, Pierre M Buekens
发表日期
2015/2/14
期刊
The Lancet
卷号
385
期号
9968
页码范围
629-639
出版商
Elsevier
简介
Background
Antenatal corticosteroids for pregnant women at risk of preterm birth are among the most effective hospital-based interventions to reduce neonatal mortality. We aimed to assess the feasibility, effectiveness, and safety of a multifaceted intervention designed to increase the use of antenatal corticosteroids at all levels of health care in low-income and middle-income countries.
Methods
In this 18-month, cluster-randomised trial, we randomly assigned (1:1) rural and semi-urban clusters within six countries (Argentina, Guatemala, India, Kenya, Pakistan, and Zambia) to standard care or a multifaceted intervention including components to improve identification of women at risk of preterm birth and to facilitate appropriate use of antenatal corticosteroids. The primary outcome was 28-day neonatal mortality among infants less than the 5th percentile for birthweight (a proxy for preterm birth) across the clusters. Use …
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