作者
Carole L Marcus, Brendan T Keenan, Jingtao Huang, Haibo Yuan, Swaroop Pinto, Ruth M Bradford, Christopher Kim, Sheila Bagchi, Francois-Louis Comyn, Stephen Wang, Ignacio E Tapia, Greg Maislin, Christopher M Cielo, Joel Traylor, Drew A Torigian, Richard J Schwab
发表日期
2017/8/1
期刊
Thorax
卷号
72
期号
8
页码范围
720-728
出版商
BMJ Publishing Group Ltd
简介
Background
The obstructive sleep apnoea syndrome (OSAS) results from a combination of structural and neuromotor factors; however, the relative contributions of these factors have not been studied during the important developmental phase of adolescence. We hypothesised that adenotonsillar volume (ATV), nasopharyngeal airway volume (NPAV), upper airway critical closing pressure (Pcrit) in the hypotonic and activated neuromotor states, upper airway electromyographic response to subatmospheric pressure and the ventilatory response to CO2 during sleep would be major predictors of OSAS risk.
Methods
42 obese adolescents with OSAS and 37 weight-matched controls underwent upper airway MRI, measurements of Pcrit, genioglossal electromyography and ventilatory response to CO2 during wakefulness and sleep.
Results
ATV, NPAV, activated and hypotonic Pcrit, genioglossal electromyography and …
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CL Marcus, BT Keenan, J Huang, H Yuan, S Pinto… - Thorax, 2017