作者
Marisa Roberto, Maureen T Cruz, Nicholas W Gilpin, Valentina Sabino, Paul Schweitzer, Michal Bajo, Pietro Cottone, Samuel G Madamba, David G Stouffer, Eric P Zorrilla, George F Koob, George R Siggins, Loren H Parsons
发表日期
2010/5/1
期刊
Biological psychiatry
卷号
67
期号
9
页码范围
831-839
出版商
Elsevier
简介
BACKGROUND
Corticotropin-releasing factor (CRF) and gamma-aminobutyric acid (GABA)ergic systems in the central amygdala (CeA) are implicated in the high-anxiety, high-drinking profile associated with ethanol dependence. Ethanol augments CeA GABA release in ethanol-naive rats and mice.
METHODS
Using naive and ethanol-dependent rats, we compared electrophysiologic effects and interactions of CRF and ethanol on CeA GABAergic transmission, and we measured GABA dialyzate in CeA after injection of CRF1 antagonists and ethanol. We also compared mRNA expression in CeA for CRF and CRF1 using real-time polymerase chain reaction. We assessed effects of chronic treatment with a CRF1 antagonist on withdrawal-induced increases in alcohol consumption in dependent rats.
RESULTS
CRF and ethanol augmented CeA GABAergic transmission in naive rats via increased GABA release …
引用总数
学术搜索中的文章
M Roberto, MT Cruz, NW Gilpin, V Sabino… - Biological psychiatry, 2010