查看文章

Typical molecular imaging methods, such as fluorescence imaging and magnetic resonance imaging (MRI), have different sensitivities, spatial resolutions, and imaging depths.[1, 2] In vivo fluorescence imaging provides high sensitivity and temporal resolution; however, penetration of visible light in living tissues is not efficient and spatial resolution is limited. MRI can produce non-invasive images with functional information and high spatial resolution anatomic details based on soft-tissue contrast; however, its sensitivity is relatively lower than other whole body imaging methods such as positron emission tomography (PET). Therefore, various multimodal imaging probes combining different imaging modalities have been developed for more accurate imaging and diagnosis.[3] For example, nanoparticles combining fluorescence imaging modality and MRI modality can offer the advantages of fluorescence imaging, ie …