作者
Marcus M Teixeira, Luiz GP de Almeida, Paula Kubitschek-Barreira, Fernanda L Alves, Érika S Kioshima, Ana KR Abadio, Larissa Fernandes, Lorena S Derengowski, Karen S Ferreira, Rangel C Souza, Jeronimo C Ruiz, Nathalia C de Andrade, Hugo C Paes, André M Nicola, Patrícia Albuquerque, Alexandra L Gerber, Vicente P Martins, Luisa DF Peconick, Alan Viggiano Neto, Claudia B Chaucanez, Patrícia A Silva, Oberdan L Cunha, Fabiana FM de Oliveira, Tayná C dos Santos, Amanda LN Barros, Marco A Soares, Luciana M de Oliveira, Marjorie M Marini, Héctor Villalobos-Duno, Marcel ML Cunha, Sybren de Hoog, José F da Silveira, Bernard Henrissat, Gustavo A Niño-Vega, Patrícia S Cisalpino, Héctor M Mora-Montes, Sandro R Almeida, Jason E Stajich, Leila M Lopes-Bezerra, Ana TR Vasconcelos, Maria SS Felipe
发表日期
2014/12
期刊
BMC genomics
卷号
15
页码范围
1-22
出版商
BioMed Central
简介
Background
The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliensis; 2) to compare S. brasiliensis, which is cat-transmitted and infects both humans and cats with S. schenckii, mainly a human pathogen; 3) to compare these two species to other human pathogens (Onygenales) with similar thermo-dimorphic behavior and to other plant-associated Sordariomycetes.
Results
The genomes of S. schenckii and S. brasiliensis were pyrosequenced to 17x and 20x coverage comprising a total of 32.3 Mb and 33.2 Mb …
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MM Teixeira, LGP de Almeida, P Kubitschek-Barreira… - BMC genomics, 2014