作者
Larry K Kociolek, William J Muller, Rebecca Yee, Jennifer Dien Bard, Cameron A Brown, Paula A Revell, Hanna Wardell, Timothy J Savage, Sarah Jung, Samuel Dominguez, Bijal A Parikh, Robert C Jerris, Sue C Kehl, Aaron Campigotto, Jeffrey M Bender, Xiaotian Zheng, Emily Muscat, Matthew Linam, Lisa Abuogi, Christiana Smith, Kelly Graff, Ariel Hernandez-Leyva, David Williams, Nira R Pollock
发表日期
2020/12/17
期刊
Journal of clinical microbiology
卷号
59
期号
1
页码范围
10.1128/jcm. 02593-20
出版商
American Society for Microbiology
简介
The distribution of upper respiratory viral loads (VL) in asymptomatic children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We assessed PCR cycle threshold (Ct) values and estimated VL in infected asymptomatic children diagnosed in nine pediatric hospital testing programs. Records for asymptomatic and symptomatic patients with positive clinical SARS-CoV-2 tests were reviewed. Ct values were (i) adjusted by centering each value around the institutional median Ct value from symptomatic children tested with that assay and (ii) converted to estimated VL (numbers of copies per milliliter) using internal or manufacturer data. Adjusted Ct values and estimated VL for asymptomatic versus symptomatic children (118 asymptomatic versus 197 symptomatic children aged 0 to 4 years, 79 asymptomatic versus 97 symptomatic children aged 5 to 9 years, 69 asymptomatic …
引用总数
2020202120222023202423633108