作者
Arnold B Mitnitski, Janice E Graham, Alexander J Mogilner, Kenneth Rockwood
发表日期
1999/2/1
期刊
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
卷号
54
期号
2
页码范围
M65-M69
出版商
The Gerontological Society of America
简介
Background. Functional impairment over time is a necessary condition for the diagnosis of dementia. Increasingly, it is recognized that rates of decline may not follow a linear progression. This variability may indicate that dementia in Alzheimer's disease represents disease rather than inevitable aging. In order to investigate decline in function in dementia, we developed a model of the rate of decline in functions in Alzheimer's disease and in other dementias in comparison with normal aging.
Methods. Secondary analysis of a cross-sectional, representative sample of Canadians aged 65 and older (N = 2,914) was performed. We calculated a measure identified as an impairment index, defined as the probability of the occurrences of an impairment or disability in a structured clinical examination.
Results. The rate of functional decline varies for …
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AB Mitnitski, JE Graham, AJ Mogilner, K Rockwood - Journals of Gerontology Series A: Biomedical Sciences …, 1999