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We consider the effectiveness of targeted vaccination at preventing the spread of infectious disease in a realistic social network. We compare vaccination strategies based on no information (random vaccination) to complete information (PageRank) about the network. The most effective strategy we find is to vaccinate those people with the most unvaccinated contacts. However, this strategy requires considerable information and computational effort which may not be practical. The next best strategies vaccinate people with many contacts who in turn have few contacts.