作者
Katherine Esposito, Paolo Chiodini, Maria Ida Maiorino, Annalisa Capuano, Domenico Cozzolino, Michela Petrizzo, Giuseppe Bellastella, Dario Giugliano
发表日期
2015/2/1
来源
BMJ open
卷号
5
期号
2
页码范围
e005892
出版商
British Medical Journal Publishing Group
简介
Objectives
To develop a nomogram for estimating the glycated haemoglobin (HbA1c) response to different dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes.
Design
A systematic review and meta-analysis of randomised controlled trials (RCTs) of DPP-4 inhibitors (vildagliptin, sitagliptin, saxagliptin, linagliptin and alogliptin) on HbA1c were conducted. Electronic searches were carried out up to December 2013. Trials were included if they were carried out on participants with type 2 diabetes, lasted at least 12 weeks, included at least 30 participants and had a final assessment of HbA1c. A random effect model was used to pool data. A nomogram was used to represent results of the metaregression model.
Participants
Adults with type 2 diabetes.
Interventions
Any DPP-4 inhibitor (vildagliptin, sitagliptin, saxagliptin, linagliptin or alogliptin).
Outcome measures
The HbA1c response to each DPP-4 inhibitor within …
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K Esposito, P Chiodini, MI Maiorino, A Capuano… - BMJ open, 2015