作者
Maria Makrides, Robert A Gibson, Andrew J McPhee, Carmel T Collins, Peter G Davis, Lex W Doyle, Karen Simmer, Paul B Colditz, Scott Morris, Lisa G Smithers, Kristyn Willson, Philip Ryan
发表日期
2009/1/14
期刊
Jama
卷号
301
期号
2
页码范围
175-182
出版商
American Medical Association
简介
Context
Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on the neurodevelopment of preterm infants.
Objective
To determine the effect of meeting the estimated DHA requirement of preterm infants on neurodevelopment at 18 months' corrected age.
Design, Setting, and Participants
Randomized, double-blind controlled trial enrolling infants born at less than 33 weeks' gestation from April 2001 to October 2005 at 5 Australian tertiary hospitals, with follow-up to 18 months.
Intervention
High-DHA (approximately 1% total fatty acids) enteral feeds compared with standard DHA (approximately 0.3% total fatty acids) from day 2 to 4 of life until term corrected age.
Main Outcome Measures
Bayley Mental Development Index (MDI) at 18 months' corrected age. A priori subgroup analyses were conducted based on randomization strata (sex and birth weight <1250 g vs ≥1250 g).
Results
Of the 657 infants …
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