作者
Kimford J Meador, Gus A Baker, Nancy Browning, Jill Clayton-Smith, Deborah T Combs-Cantrell, Morris Cohen, Laura A Kalayjian, Andres Kanner, Joyce D Liporace, Page B Pennell, Michael Privitera, David W Loring
发表日期
2009/4/16
期刊
New England journal of medicine
卷号
360
期号
16
页码范围
1597-1605
出版商
Massachusetts Medical Society
简介
Background
Fetal exposure of animals to antiepileptic drugs at doses lower than those required to produce congenital malformations can produce cognitive and behavioral abnormalities, but cognitive effects of fetal exposure of humans to antiepileptic drugs are uncertain.
Methods
Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom. The primary analysis is a comparison of neurodevelopmental outcomes at the age of 6 years after exposure to different antiepileptic drugs in utero. This report focuses on a planned interim analysis of cognitive outcomes in 309 children at 3 years of age.
Results
At 3 years of age, children who had been exposed to valproate in utero had significantly lower IQ scores than those …
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KJ Meador, GA Baker, N Browning, J Clayton-Smith… - New England journal of medicine, 2009