作者
Alassane Dicko, Jean-Bosco Ouedraogo, Issaka Zongo, Issaka Sagara, Matthew Cairns, Rakiswendé Serge Yerbanga, Djibrilla Issiaka, Charles Zoungrana, Youssoufa Sidibe, Amadou Tapily, Frédéric Nikièma, Frédéric Sompougdou, Koualy Sanogo, Mahamadou Kaya, Hama Yalcouye, Oumar Mohamed Dicko, Modibo Diarra, Kalifa Diarra, Ismaila Thera, Alassane Haro, Abdoul Aziz Sienou, Seydou Traore, Almahamoudou Mahamar, Amagana Dolo, Irene Kuepfer, Paul Snell, Jane Grant, Jayne Webster, Paul Milligan, Cynthia Lee, Christian Ockenhouse, Opokua Ofori-Anyinam, Halidou Tinto, Abdoulaye Djimde, Daniel Chandramohan, Brian Greenwood
发表日期
2024/1/1
期刊
The Lancet Infectious Diseases
卷号
24
期号
1
页码范围
75-86
出版商
Elsevier
简介
Background
Seasonal vaccination with the RTS,S/AS01E vaccine combined with seasonal malaria chemoprevention (SMC) prevented malaria in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether the added protection provided by the combination could be sustained for a further 2 years.
Methods
This was a double-blind, individually randomised, controlled, non-inferiority and superiority, phase 3 trial done at two sites: the Bougouni district and neighbouring areas in Mali and Houndé district, Burkina Faso. Children who had been enrolled in the initial 3-year trial when aged 5–17 months were initially randomly assigned individually to receive SMC with sulphadoxine-pyrimethamine and amodiaquine plus control vaccines, RTS,S/AS01E plus placebo SMC, or SMC plus RTS,S/AS01E. They continued to receive the same …
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A Dicko, JB Ouedraogo, I Zongo, I Sagara, M Cairns… - The Lancet Infectious Diseases, 2024