作者
Michal Fried, Jonathan D Kurtis, Bruce Swihart, Sunthorn Pond-Tor, Amadou Barry, Youssoufa Sidibe, Santara Gaoussou, Moussa Traore, Sekouba Keita, Almahamoudou Mahamar, Oumar Attaher, Adama B Dembele, Kadidia B Cisse, Bacary S Diarra, Moussa B Kanoute, Alassane Dicko, Patrick E Duffy
发表日期
2017/10/30
期刊
Clinical Infectious Diseases
卷号
65
期号
10
页码范围
1729-1735
出版商
Oxford University Press
简介
Background
Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor–α, interferon-γ, interleukin 10 (IL-10), and CXCL9. These changes are associated with poor outcomes including low birthweight delivery and maternal anemia. However, it is unknown if inflammatory pathways during malaria are related to pregnancy loss and preterm delivery (PTD).
Methods
Cytokine and chemokine levels were measured in maternal peripheral blood at enrollment, gestational week 30–32, and delivery, and in placental blood, of 638 women during a longitudinal cohort study in Ouelessebougou, Mali. Plasmodium falciparum infection was assessed by blood smear microscopy at all visits.
Results
PM was associated with increased levels of cytokines and …
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M Fried, JD Kurtis, B Swihart, S Pond-Tor, A Barry… - Clinical Infectious Diseases, 2017