作者
Benjamin D Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L Vera, Yanli Wang, R Scott Hansen, Theresa K Canfield, Robert E Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H Dennis, Michael P Snyder, John A Stamatoyannopoulos, James Taylor, Ross C Hardison, Tamer Kahveci, Bing Ren, David M Gilbert
发表日期
2014/11/20
期刊
Nature
卷号
515
期号
7527
页码范围
402-405
出版商
Nature Publishing Group UK
简介
Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell-type-specific with at least half the genome switching replication timing during development, primarily in units of 400–800 kilobases (‘replication domains’), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements,,,,,. Early and late replication correlate, respectively, with open and closed three-dimensional chromatin compartments identified by high-resolution chromosome conformation capture (Hi-C), and, to a lesser extent, late replication correlates with lamina-associated domains (LADs),,,. Recent Hi-C mapping has unveiled substructure within chromatin compartments called topologically associating domains (TADs) that are largely conserved in their positions between cell types and …
学术搜索中的文章
BD Pope, T Ryba, V Dileep, F Yue, W Wu, O Denas… - Nature, 2014