作者
Linjie Zhang, Raúl A Mendoza-Sassi, Terry P Klassen, Claire Wainwright
发表日期
2015/10/1
来源
Pediatrics
卷号
136
期号
4
页码范围
687-701
出版商
American Academy of Pediatrics
简介
BACKGROUND AND OBJECTIVE
The mainstay of treatment for acute bronchiolitis remains supportive care. The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis.
METHODS
Data sources included PubMed and the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information up to May 2015. Studies selected were randomized or quasi-randomized controlled trials comparing nebulized HS with 0.9% saline or standard treatment.
RESULTS
We included 24 trials involving 3209 patients, 1706 of whom received HS. Hospitalized patients treated with nebulized HS had a significantly shorter length of stay compared with those receiving 0.9% saline or standard care (15 trials involving 1956 patients; mean difference [MD] −0.45 days, 95% confidence …
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L Zhang, RA Mendoza-Sassi, TP Klassen… - Pediatrics, 2015