作者
Aniela I Pruteanu, Bhupendrasinh F Chauhan, Linjie Zhang, Sílvio OM Prietsch, Francine M Ducharme
发表日期
2014/12
来源
Evidence‐based Child Health: a Cochrane review journal
卷号
9
期号
4
页码范围
931-1046
出版商
John Wiley & Sons, Ltd.
简介
Background
Inhaled corticosteroids (ICS) are the first‐line treatment for children with persistent asthma. Their potential for growth suppression remains a matter of concern for parents and physicians.
Objectives
To assess whether increasing the dose of ICS is associated with slower linear growth, weight gain and skeletal maturation in children with asthma.
Search methods
We searched the Cochrane Airways Group Specialised Register of trials (CAGR) and the ClinicalTrials.gov website up to March 2014.
Selection criteria
Studies were eligible if they were parallel‐group randomised trials evaluating the impact of different doses of the same ICS using the same device in both groups for a minimum of three months in children one to 17 years of age with persistent asthma.
Data collection and analysis
Two review authors ascertained methodological quality independently using the Cochrane Risk of bias tool. The …
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AI Pruteanu, BF Chauhan, L Zhang, SOM Prietsch… - Evidence‐based Child Health: a Cochrane review …, 2014