作者
Lili Chen, Jiajia Zhao, Jinfeng Peng, Xiaoshuang Li, Xuliang Deng, Zhi Geng, Zhenyu Shen, Fengyuan Guo, Qianwen Zhang, Yang Jin, Lin Wang, Songlin Wang
发表日期
2020/12
期刊
Cell proliferation
卷号
53
期号
12
页码范围
e12923
简介
Objectives
In order to provide a more comprehensive understanding of the effects of SARS‐CoV‐2 on oral health and possible saliva transmission, we performed RNA‐seq profiles analysis from public databases and also a questionnaire survey on oral‐related symptoms of COVID‐19 patients.
Materials and methods
To analyse ACE2 expression in salivary glands, bulk RNA‐seq profiles from four public datasets including 31 COVID‐19 patients were recruited. Saliva and oropharyngeal swabs were collected. SARS‐CoV‐2 nucleic acids in saliva were detected by real‐time polymerase chain reaction (RT‐PCR). Additionally, a questionnaire survey on various oral symptoms such as dry mouth and amblygeustia was also carried out on COVID‐19 patients.
Results
ACE2 expression was present at detectable levels in the salivary glands. In addition, of four cases with positive detection of salivary SARS‐CoV‐2 …
学术搜索中的文章
L Chen, J Zhao, J Peng, X Li, X Deng, Z Geng, Z Shen… - Cell proliferation, 2020
