查看文章

Patients on high‐dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate‐related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology remains unknown, and appropriate therapy is not established. Here we have developed a mouse model of BRONJ‐like disease that recapitulates major clinical and radiographic manifestations of the human disease, including characteristic features of an open alveolar socket, exposed necrotic bone or sequestra, increased inflammatory infiltrates, osseous sclerosis, and radiopaque alveolar bone. We show that administration of zoledronate, a potent aminobisphosphonate, and dexamethasone, an immunosuppressant drug, causes BRONJ‐like disease in mice in part by suppressing the adaptive regulatory T cells, Tregs, and activating the inflammatory T‐helper‐producing interleukin 17 cells, Th17. Most …