作者
Peter Marckmann, Hanne Agerskov, Sasikala Thineshkumar, Else-Marie Bladbjerg, Johannes J Sidelmann, Jørgen Jespersen, Mads Nybo, Lars M Rasmussen, Ditte Hansen, Alexandra Scholze
发表日期
2012/9/1
期刊
Nephrology Dialysis Transplantation
卷号
27
期号
9
页码范围
3523-3531
出版商
Oxford University Press
简介
Background
Hypovitaminosis D is common in chronic kidney disease (CKD). Effects of 25-hydroxyvitamin D replenishment in CKD are not well described.
Methods
An 8-week randomized, placebo-controlled, double-blind parallel intervention study was conducted in haemodialysis (HD) and non-HD CKD patients. Treatment consisted of 40 000 IU of cholecalciferol orally per week. Plasma 25-hydroxyvitamin D (25-OHD), plasma 1,25-dihydroxyvitamin D (1,25-diOHD), plasma parathyroid hormone (PTH), serum phosphate, ionized serum calcium and serum fibroblast growth factor 23 (FGF-23) were analysed. We also investigated biomarkers related to cardiovascular disease (plasma D-dimer, plasma fibrinogen, plasma von Willebrand factor antigen and activity, plasma interleukin 6, plasma C-reactive protein, blood pressure, aortic augmentation index, aortic pulse wave velocity …
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P Marckmann, H Agerskov, S Thineshkumar… - Nephrology Dialysis Transplantation, 2012