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The expression of CCL5/Rantes by Hodgkin (H) and Reed‐Sternberg (RS) cells has been recently documented. In the present study we demonstrated that the CCL5 receptor (CCR5) is constitutively expressed by Hodgkin Lymphoma (HL)‐derived cell lines (i.e. L‐428, KM‐H2, L‐1236 and L‐540) as shown by immunohistochemistry, flow cytometry and western blotting and also detected by immunohistochemistry on primary H‐RS cells from lymph node tissues. sCD40L never significantly affected CCR5 expression, whereas a short exposure to doxorubicin down regulated its expression. CCR5 receptors on HL cell lines were functionally active, since neutralizing anti‐CCL5 monoclonal antibodies inhibited basal proliferation of HL‐derived cell lines and recombinant CCR5 ligands (CCL3/Mip‐1α, CCL4/Mip1β and CCL5/Rantes) increased their clonogenic growth. CCL5 secretion by L‐1236, L‐428 and KM‐H2 cells …