作者
Vanessa Schopf Machado, Nathieli B Bottari, Matheus D Baldissera, Virginia C Rech, Francine R Ianiski, Cristiane Signor, Maribel A Rubin, Emily P Waczuk, Claiton I Schwertz, Ricardo E Mendes, Giovana Camillo, Fernanda F Vogel, Mario L de la Rue, Vera M Morsch, Maria Rosa C Schetinger, Pâmella KS Frühauf, Aleksandro S Da Silva
发表日期
2016/10/1
期刊
Experimental parasitology
卷号
169
页码范围
51-58
出版商
Academic Press
简介
The aim of this study was to evaluate the effect of subcutaneous administration of diphenyl diselenide (PhSe)2 on animal behavior and activities of acetylcholinesterase (AChE), adenylate kinase (AK), and creatine kinase (CK) in the brain of mice infected by Toxoplasma gondii. In addition, thiobarbituric acid reactive species (TBARS) levels and glutathione (GR, GPx and GST) activity were also evaluated. For the study, 40 female mice were divided into four groups of 10 animals each: group A (uninfected and untreated), group B (uninfected and treated with (PhSe)2), group C (infected and untreated) and group D (infected and treated with (PhSe)2). The mice were inoculated with 50 cysts of the ME49 strain of T. gondii. After infection the animals of the groups B and D were treated on days 1 and 20 post-infection (PI) with 5.0 μmol/kg of (PhSe)2 subcutaneously. Behavioral tests were conducted on days 29 PI to assess …
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VS Machado, NB Bottari, MD Baldissera, VC Rech… - Experimental parasitology, 2016