作者
Sébastien Hantz, Françoise Garnier-Geoffroy, Marie-Christine Mazeron, Isabelle Garrigue, Pierre Merville, Catherine Mengelle, Lionel Rostaing, Franck Saint Marcoux, Marie Essig, Jean-Philippe Rerolle, Sébastien Cotin, Raphaëlle Germi, Sylvie Pillet, Yvon Lebranchu, Pascal Turlure, Sophie Alain, French CMV Resistance Survey Study Group, Georges Herbein, Alain Coaquette, Marie Edith Lafon, Isabelle Garrigue, Christine Archimbaud, Cécile Henquell, Hélène Peigue-Lafeuille, Pierre Pothier, Jean Baptiste Bour, Raymond Cesaire, Fatimah Majioullah, Patrice Morand, Raphaëlle Germi, Christine Morel-Baccard, Anne Signori-Schmuck, Sophie Alain, Sébastien Hantz, Jérôme Grosjean, Florence Morfin-Sherpa, Geneviève Billaud, Vinca Domenach, Patrice Andre, Marie Paule Milon, Michel Segondy, Vincent Foulongne, Gérard Agius, Agnès Beby-Defaux, Bruno Pozzetto, Sylvie Pillet, Jean Michel Mansuy, Catherine Mengelle, Sandrine Gaudio-Castelain, Alexandra Ducancelle, Françoise Lunel, Christopher Payan, Stéphanie Gouarin, Anny Dewilde, Céline Bressolette, Marianne Coste-Burel, Berthe-Marie Imbert-Marcille, Laurent Andreoletti, Nicolas Leveque, Véronique Venard, Hélène Jeulin, Sophie Minjolle, Marie Gueudin, Ronald Colimon, Françoise Stoll-Keller, Samira Fafi-Kremer, F Dubois, Catherine Gaudy, Paul Deny, Françoise Brun Vezinet, Nadira Houhou, Patrick Honderlick, Marie Christine Mazeron, Marianne Leruez-Ville, Parissa Vaghefi, Elisabeth Dussaix, Henri Agut, David Boutolleau, Claire Deback, Catherine Scieux, Jérôme Le Goff, Didier Ducloux, Claire Vanlemmens, Fabrice Larosa, M Neau-Cransac, C Dromer, Emmanuelle Rosier, Pierre Merville, Marine Douillet, Delphine Morel, Karine Moreau, Séverine Martin, Marc-Alain Billes, Noel Milpied, Reza Tabrizi, Stéphane Vigouroux, Cyril Melot, Patrice Deteix, Anne-Elisabeth Heng, Léandre Mackaya, Sandrine Casanova, Jacques-Olivier Bay, François Demeocq, Frédéric Duee, Christiane Mousson, Patrick Hillon, Anne Minello, Philippe Charve, Yves Tanter, François Bayle, Bénédicte Janbon, Elisabeth Borrel, Aude Boignard, Linda Neron, Christophe Pison, Christel Saint-Raymond, Jean Paul Brion, Jean Yves Cahn, Dominique Bordessoule, Pascal Turlure, Frédérica Bompart, Céline Philippon, Marie Essig, Jean-Claude Aldigier, Jean Philippe Rerolle, Zarah Dickson, Valérie Leprivey, Florence Roger-Rolle, Christophe Piguet, Pierre Marquet, Bruno Francois, Claire Pouteil-Noble, Valérie Mialou, Georges Mourad, Christophe Mariat, Jérôme Cornillon, Emmanuelle Tavernie-Tardy, M Attal, Anne Huynh, Lionel Rostaing, Nassim Kamar, Danièle Mencia, Laure Crognier, Bruno Hurault de Ligny, Marc Hazzan, Pierre Bordigoni, Sandrine Pall-Kondolff, Alexandra Salmon, Laurence Clement, Patrice Chevallier
发表日期
2010/12/1
期刊
Journal of antimicrobial chemotherapy
卷号
65
期号
12
页码范围
2628-2640
出版商
Oxford University Press
简介
Objectives
Cytomegalovirus (CMV) drug resistance is a therapeutic challenge in the transplant setting. No longitudinal cohort studies of CMV resistance in a real-life setting have been published in the valganciclovir era. We report findings for a French multicentre prospective cohort of 346 patients enrolled at initial diagnosis of CMV infection (clinical trial registered at clinicaltrials.gov: NCT01008540).
Patients and methods
Patients were monitored for detection of CMV infection for ≥2 years. Real-time detection of resistance by UL97 and UL54 gene sequencing and antiviral phenotyping was performed if viral replication persisted for >21 days of appropriate antiviral treatment. Plasma ganciclovir assays were performed when resistance was suspected.
Results
Resistance was suspected in 37 (10.7%) patients; 18/37 (5.2% of the cohort) had virological …
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S Hantz, F Garnier-Geoffroy, MC Mazeron, I Garrigue… - Journal of antimicrobial chemotherapy, 2010