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The thought translation device trains locked-in patients to self regulate slow cortical potentials (SCP's) of their electroencephalogram (EEG). After operant learning of SCP self control, patients select letters, words or pictograms in a computerized language support program. Results of five respirated, locked-in-patients are described, demonstrating the usefulness of the thought translation device as an alternative communication channel in motivated totally paralyzed patients with amyotrophic lateral sclerosis.