作者
Gunter Schumann, Eva Loth, Tobias Banaschewski, A Barbot, G Barker, C Büchel, Patricia J Conrod, JW Dalley, Herta Flor, Jürgen Gallinat, Hugh Garavan, Andreas Heinz, B Itterman, Mark Lathrop, C Mallik, K Mann, Jean-Luc Martinot, Tomas Paus, Jean Baptiste Poline, Trevor W Robbins, Marcella Rietschel, L Reed, M Smolka, Rainer Spanagel, C Speiser, DN Stephens, A Ströhle, Maren Struve
发表日期
2010/12
来源
Molecular psychiatry
卷号
15
期号
12
页码范围
1128-1139
出版商
Nature Publishing Group
简介
A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study aimed at identifying the genetic and neurobiological basis of individual variability in impulsivity, reinforcer sensitivity and emotional reactivity, and determining their predictive value for the development of frequent psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents are combined with functional genetics in animal and human models. Results will be validated in 1000 adolescents from the Canadian Saguenay Youth Study. The sample will be followed up longitudinally at the age of 16 years to investigate the predictive value of genetics and intermediate …
引用总数
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G Schumann, E Loth, T Banaschewski, A Barbot… - Molecular psychiatry, 2010