作者
Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H Beck, Anant Madabhushi, Johan Hartman, Manu M Sebastian, Hugo M Horlings, Jan Hudeček, Francesco Ciompi, David A Moore, Rajendra Singh, Elvire Roblin, Marcelo Luiz Balancin, Marie-Christine Mathieu, Jochen K Lennerz, Pawan Kirtani, I-Chun Chen, Jeremy P Braybrooke, Giancarlo Pruneri, Sandra Demaria, Sylvia Adams, Stuart J Schnitt, Sunil R Lakhani, Federico Rojo, Laura Comerma, Sunil S Badve, Mehrnoush Khojasteh, W Fraser Symmans, Christos Sotiriou, Paula Gonzalez-Ericsson, Katherine L Pogue-Geile, Rim S Kim, David L Rimm, Giuseppe Viale, Stephen M Hewitt, John MS Bartlett, Frédérique Penault-Llorca, Shom Goel, Huang-Chun Lien, Sibylle Loibl, Zuzana Kos, Sherene Loi, Matthew G Hanna, Stefan Michiels, Marleen Kok, Torsten O Nielsen, Alexander J Lazar, Zsuzsanna Bago-Horvath, Loes FS Kooreman, Jeroen AWM van der Laak, Joel Saltz, Brandon D Gallas, Uday Kurkure, Michael Barnes, Roberto Salgado, Lee AD Cooper
发表日期
2020/5/12
来源
NPJ Breast Cancer
卷号
6
期号
1
页码范围
1-13
出版商
Nature Publishing Group
简介
Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training …
学术搜索中的文章
M Amgad, ES Stovgaard, E Balslev, J Thagaard… - NPJ breast cancer, 2020