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Endometriosis is a chronic estrogen-dependent disease affecting 5–10% of women in reproductive age (1). Although it can be asymptomatic in a minority of the cases, the main symptoms and signs include chronic pelvic pain, dysmenorrhea, pain during intercourse, abnormal uterine bleeding and infertility, which may cause severe impact on patient’s psychological wellbeing and quality of life (2). The disease is characterized by ectopic endometrial-like tissue (glands and stroma) that induces a chronic inflammatory response, adhesions, and scar tissue that alter pelvic anatomy (3). From the clinical point of view, endometriosis was subdivided in peritoneal superficial lesions, ovarian cysts (endometriomas) and deep infiltrating endometriosis, and usually scored according to the revised American Fertility Society classification (rAFS)(1) in four stages: minimal, mild, moderate and severe. Among the several theories …