作者
Phillipe D O'Brien, Lucy M Hinder, Brian C Callaghan, Eva L Feldman
发表日期
2017/6/1
来源
The Lancet Neurology
卷号
16
期号
6
页码范围
465-477
出版商
Elsevier
简介
The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development. In the peripheral nervous system, obesity-driven alterations in the autonomic nervous system prompt imbalances in sympathetic–parasympathetic activity, while alterations in the sensory–somatic nervous system underlie peripheral polyneuropathy, a common complication of diabetes. Pharmacotherapy and …
学术搜索中的文章
PD O'Brien, LM Hinder, BC Callaghan, EL Feldman - The Lancet Neurology, 2017