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It has been well documented that workplace stress can have a negative impact on nurse well-being and productivity, and can result in the syndrome of compassion fatigue, which is comprised of secondary traumatic stress and burnout. Identifying effective and practical workplace interventions to help improve nurse resilience to prevent compassion fatigue is therefore a high priority. This study trialled the effectiveness of a brief mindful self-care and resiliency intervention for nurses working in an Australian tertiary hospital compared to nurses in a wait list control condition. A total of 91 nurses participated in the study (n = 65 intervention condition; n = 26 control condition). The intervention involved a 1-day workshop followed by three weekly mindfulness practice sessions. Nurses completed measures of burnout, secondary traumatic stress, negative mood, self-compassion, compassion satisfaction, subjective …