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Background: Low vitamin D level was observed among adults with prediabetes and diabetes mellitus. Insulin resistance is the hallmark in the pathogenesis of them. Vitamin D deficiency is thought to influence the pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity, β-cell function or both.

Aims: To determine the level of serum vitamin D, intact parathyroid hormone (iPTH) and insulin resistance and their association in adults with prediabetes.

Methods: This cross-sectional study was carried out in 115 newly detected adults with prediabetes diagnosed according to American Diabetes Association 2018 criteria. Participants were recruited consecutively from the Department of Endocrinology, BSMMU to measure serum 25hydroxyvitamin D by high performance liquid chromatography method, intact parathyroid hormone was measured by chemiluminescent enzyme-labeled immunometric assay and fasting insulin was measured by chemiluminescent microparticle immunoassay to calculate homeostasis model assessment of insulin resistance (HOMA-IR).

Results: The frequency of vitamin D deficiency was 46.1% in adults with prediabetes. There were no significant association between vitamin D (p= 0.39) oriPTH (p= 0.55) level with insulin resistance status in adults with prediabetes. No significant correlations were found between vitamin D level (r=-0.07, p= 0.44) and intact parathyroid hormone level (r= 0.08, p= 0.37) with HOMA-IR.

Conclusion: A substantial proportion of prediabetes was vitamin D deficient. There was no association or correlation between vitamin D and insulin resistance among adults with prediabetes.