作者
Nancy Diazgranados, Lobna Ibrahim, Nancy E Brutsche, Andrew Newberg, Phillip Kronstein, Sami Khalife, William A Kammerer, Zenaide Quezado, David A Luckenbaugh, Giacomo Salvadore, Rodrigo Machado-Vieira, Husseini K Manji, Carlos A Zarate
发表日期
2010/8/1
期刊
Archives of general psychiatry
卷号
67
期号
8
页码范围
793-802
出版商
American Medical Association
简介
Context
Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects—for instance, within a few hours or days—would have an enormous impact on patient care and public health.
Objective
To determine whether anN-methyl-D-aspartate–receptor antagonist produces rapid antidepressant effects in subjects with bipolar depression.
Design
A randomized, placebo-controlled, double-blind, crossover, add-on study conducted from October 2006 to June 2009.
Setting
Mood Disorders Research Unit at the National Institute of Mental Health, Bethesda, Maryland.
Patients
Eighteen subjects withDSM-IVbipolar depression (treatment-resistant).
Interventions
Subjects maintained at therapeutic levels of lithium or valproate received an intravenous infusion of either ketamine hydrochloride (0.5 mg/kg) or placebo on 2 test days 2 weeks apart …
引用总数
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N Diazgranados, L Ibrahim, NE Brutsche, A Newberg… - Archives of general psychiatry, 2010