作者
Naglaa S Elabd, Shimaa E Soliman, Moamena S Elhamouly, Suzy F Gohar, Ayman Elgamal, Mahmoud Magdy Alabassy, Haitham A Soliman, Abdelnaser A Gadallah, Osama D Elbahr, Ghada Soliman, Amany A Saleh
发表日期
2022/1/1
期刊
The Application of Clinical Genetics
页码范围
97-109
出版商
Taylor & Francis
简介
Background
We aimed to evaluate the diagnostic roles of AFAP1-AS1 and ASB16-AS1 in colorectal cancer and highlight their roles in predicting colorectal cancer patients’ prognosis.
Methods
In this case–control study, 146 participants were involved. Group I included 47 patients with CRC. Group II composed of 49 patients with benign lesions in the colon, and Group III included 50 apparently normal subjects of coincided age and gender as controls. All participants were subjected to clinical and endoscopic evaluations, CA19-9, CEA, and quantification of relative expression of lncRNAs ASB16-AS1 and AFAP1-AS1.
Results
CRC patients had significantly elevated expression levels of both lncRNAs in tissue and plasma samples versus benign and control groups (p < 0.001). Despite the higher sensitivity of tissue samples results, the relative expression of both lncRNAs in plasma samples was very encouraging in the …
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NS Elabd, SE Soliman, MS Elhamouly, SF Gohar… - The Application of Clinical Genetics, 2022