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Results:

There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P< 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P= 0.003), performance status 2 (P= 0.009), stage IV (P< 0.001), and presence of metastasis (P< 0.001). GLUT1 expression showed nonsignificant association with overall survival (P= 0.068), while tumor stage (P= 0.01) and metastasis (P= 0.009) were significantly associated with lower overall survival.

Conclusion:

GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival.