作者
Sebastian Weis, André Scherag, Michael Baier, Michael Kiehntopf, Thomas Kamradt, Steffi Kolanos, Juliane Ankert, Stefan Glöckner, Oliwia Makarewicz, Stefan Hagel, Christina Bahrs, Aurelia Kimmig, Hans Proquitté, Joel Guerra, Dagmar Rimek, Bettina Löffler, Mathias W Pletz, Thomas Hotz, Local Cooperation Partners, Petra Enders, Renate Koch, Steffen Mai, Matthias Ullrich, Cora Richert, Cornelius Eibner, Bettina Meinung, Kay Stötzer, Julia Köhler, Hans Cipowicz, Christine Pinkwart, Michael Bauer, Petra Dickmann, Annika Licht, Juliane Scholz, Wibke Wetzker, Anita Hartung, Daniel Weiss, Lara Thieme, Gabi Hanf, Clara Schnizer, Jasmin Müller, Jennifer Kosenkow, Franziska Röstel, Nico Andreas, Raphaela Marquardt, Stefanie Deinhardt-Emmer, Sebastian Kuhn
发表日期
2021/3/1
期刊
Clinical Microbiology and Infection
卷号
27
期号
3
页码范围
470. e1-470. e9
出版商
Elsevier
简介
Objectives
Due to a substantial proportion of asymptomatic and mild courses, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed to determine and characterize the rate of SARS-CoV-2 infections and the resulting seroprevalence in a defined population. The primary objective of the study was to assess SARS-CoV-2 antibody seroprevalence using six different IgG-detecting immunoassays. Secondary objectives of the study were: (a) to determine potential risk factors for symptomatic versus asymptomatic coronavirus disease 2019 courses, and (b) to investigate the rate of virus RNA-persistence.
Methods
CoNAN is a population-based cohort study performed in the community Neustadt am Rennsteig, Germany, which was quarantined from 22 March to 5 April after six SARS-CoV-2 …
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S Weis, A Scherag, M Baier, M Kiehntopf, T Kamradt… - Clinical Microbiology and Infection, 2021