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The objective of this study was to assess the costs associated with a group behavioral weight loss intervention and compare cost‐effectiveness based on treatment delivery modality (in‐person vs. Internet). A randomized controlled trial examined efficacy of a group behavioral obesity intervention across in‐person and Internet treatment modalities. Participants (N = 323, 93% women, mean BMI = 35.8) from two centers were randomized to treatment modality, and contact time was matched between conditions. Primary outcome was weight loss. Cost‐effectiveness measures calculated life years gained (LYG) from changes in weight at 6 months, based on excess years of life lost (YLL) algorithm and the cost of the two modalities. In‐person participants had significantly greater weight losses (−8.0 ± 6.1 kg) than Internet participants (−5.5 ± 5.6 kg), whereas differences in LYG were insignificant. Estimated LYG was 0.58 …