查看文章

Noble metal nanoparticles are promising materials for heterogeneous enantioselective catalysis because of their high surface-to-volume ratios, large concentrations of highly undercoordinated surface sites, and quantum confinement effects. In this work, we report on the use of DNA as an environment-responsive chiral ligand to engineer the selective catalytic behaviors of glucose oxidase-mimicking gold nanoparticles (AuNPs), with glucose enantiomers as the substrates. DNA can be stimulated externally to switch between random-coiled and multistranded structures (e.g., duplex, i-motif, or G-quadruplex). Random-coiled DNA-capped nanoparticles preferentially catalyze oxidation of l-glucose, and structured DNA-capped nanoparticles show higher activity toward d-glucose. pH-induced selectivity diminishment of DNA-treated AuNPs is also found, further demonstrating the chiral selector effect of DNA ligands. In the …