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Human T cell lymphotropic virus type 2 (HTLV-2) infection is endemic in the American Indian population and Pygmy tribes in Africa. Nevertheless, HTLV-2 infection has been predominantly detected in U.S. and European injecting drug users (IDU). Noteworthy is that the HTLV-2a subtype is the main circulating variant in North America and Eastern Europe whereas the HTLV-2b subtype is mainly found in Western Europe, particularly in Italy and Spain where coinfection with HIV-1 is frequent. Twelve Spanish subjects infected with HTLV-2 were recruited for the study. All of them were IDUs coinfected with HIV-1. Molecular epidemiology was done by sequencing the LTR, env, and tax regions and by generating phylogenetic trees. The present study showed that all the sequences belonged to the HTLV-2b subtype and were closely related to other Spanish and Portuguese reported sequences, clearly differentiated from …