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Skeletal muscle injury by hypolipidemic drugs is not fully understood. An extensive analysis of the effect of chronic treatment with fluvastatin (5 mgkg^‐1 and 20 mgkg^‐1), atorvastatin (10 mgkg^‐1) and fenofibrate (60 mgkg^‐1) on rat skeletal muscle was undertaken.

Myoglobinemia as sign of muscle damage was measured by enzymatic assay. Histological and immunohistochemical techniques were used to estimate muscle integrity and the presence of aquaporin‐4, a protein controlling water homeostasis. Electrophysiological evaluation of muscle Cl^‐ conductance (gCl) and mechanical threshold (MT) for contraction, index of intracellular calcium homeostasis, was performed by the two‐intracellular microelectrodes technique.

Fluvastatin (20 mgkg^‐1) increased myoglobinemia. The lower dose of fluvastatin did not modify myoglobinemia, but reduced …