作者
Brigham & Women’s Hospital & Harvard Medical School Chin Lynda 9 11 Park Peter J. 12 Kucherlapati Raju 13, Genome data analysis: Baylor College of Medicine Creighton Chad J. 22 23 Donehower Lawrence A. 22 23 24 25, Institute for Systems Biology Reynolds Sheila 31 Kreisberg Richard B. 31 Bernard Brady 31 Bressler Ryan 31 Erkkila Timo 32 Lin Jake 31 Thorsson Vesteinn 31 Zhang Wei 33 Shmulevich Ilya 31, Oregon Health & Science University Anur Pavana 37 Spellman Paul T. 37, NCI Yan Chunhua 44 Hu Ying 44 Meerzaman Daoud 44, Tissue source sites: ABS-IUPUI Tarvin Katie 48 Saller Charles 49 Sandusky George 50 Mitchell Colleen 50, Christiana Iacocca Mary V. 51 Brown Jennifer 51 Rabeno Brenda 51 Czerwinski Christine 51 Petrelli Nicholas 51, Cureline Dolzhansky Oleg 52 Abramov Mikhail 53 Voronina Olga 54 Potapova Olga 54, Duke University Medical Center Marks Jeffrey R. 55, ILSBio Van Le Xuan 58 Kohl Bernard 58 Viet Tien Nguyen 59 Thorp Richard 60 Van Bang Nguyen 61 Sussman Howard 62 Duc Phu Bui 61 Hajek Richard 63 Phi Hung Nguyen 64 Viet The Phuong Tran 65 Quyet Thang Huynh 66 Zaki Khan Khurram 60, International Genomics Consortium Penny Robert 67 Mallery David 67 Curley Erin 67 Shelton Candace 67 Yena Peggy 67, Mayo Clinic Ingle James N. 68 Couch Fergus J. 68 Lingle Wilma L. 68, MSKCC King Tari A. 69, MD Anderson Cancer Center Maria Gonzalez-Angulo Ana 38 70 Mills Gordon B. 70 Dyer Mary D. 70 Liu Shuying 70 Meng Xiaolong 70 Patangan Modesto 70, University of California San Francisco Waldman Frederic 71 92 72 93 Stöppler Hubert 73, University of North Carolina Kimryn Rathmell W. 15 Thorne Leigh 15 74 Huang Mei 15 74 Boice Lori 15 74 Hill Ashley 15, Roswell Park Cancer Institute Morrison Carl 75 Gaudioso Carmelo 75 Bshara Wiam 75, University of Miami Daily Kelly 76 Egea Sophie C. 76 Pegram Mark D. 76 Gomez-Fernandez Carmen 76, University of Pittsburgh Dhir Rajiv 77 Bhargava Rohit 78 Brufsky Adam 78, Walter Reed National Military Medical Center Shriver Craig D. 79 Hooke Jeffrey A. 79 Leigh Campbell Jamie 79 Mural Richard J. 80 Hu Hai 80 Somiari Stella 80 Larson Caroline 80 Deyarmin Brenda 80 Kvecher Leonid 80 Kovatich Albert J. 81, Project team: National Cancer Institute Sheth Margi 88 Demchok John A. 88 Mills Shaw Kenna R. 88 Yang Liming 88 Eley Greg 89 Ferguson Martin L. 90 Tarnuzzer Roy W. 88 Zhang Jiashan 88 Dillon Laura AL 88 Buetow Kenneth 44 Fielding Peter 88, National Human Genome Research Institute Ozenberger Bradley A. 91 Guyer Mark S. 91 Sofia Heidi J. 91 Palchik Jacqueline D. 91
发表日期
2012/10/4
期刊
Nature
卷号
490
期号
7418
页码范围
61-70
出版商
Nature Publishing Group UK
简介
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3, PIK3CA and MAP3K1 with the luminal A subtype. We identified two novel protein-expression-defined subgroups, possibly produced by stromal/microenvironmental elements …
引用总数
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