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To measure the variability of T_1ρ relaxation times using CubeQuant, T₂ relaxation times using quantitative double echo in steady state (DESS), and normalized sodium signals using 3D cones sodium magnetic resonance imaging (MRI) of knee cartilage in vivo at 3 T.

Eight healthy subjects were scanned at 3 T at baseline, 1 day, 5 months, and 1 year. Ten regions of interest (ROIs) of knee cartilage were segmented in the medial and lateral compartments of each subject's knee. T_1ρ and T₂ relaxation times and normalized sodium signals were measured and the root-mean-square coefficient of variation (CV_RMS) was calculated. Intra-subject variability was measured over short, moderate and long-term, as well as intra-observer and inter-observer variability.

The average intra-subject CV_RMS measurements over short, moderate, and long-term time periods were 4.6%, 6.1%, and 6.0% for the T …