作者
Theresa Guo, Jesse R Qualliotine, Patrick K Ha, Joseph A Califano, Young Kim, John R Saunders, Ray G Blanco, Gypsyamber D'Souza, Zhe Zhang, Christine H Chung, Ana Kiess, Christine G Gourin, Wayne Koch, Jeremy D Richmon, Nishant Agrawal, David W Eisele, Carole Fakhry
发表日期
2015/6/15
期刊
Cancer
卷号
121
期号
12
页码范围
1977-1984
简介
BACKGROUND
Human papillomavirus (HPV) tumor status and surgical salvage are associated with improved prognosis for patients with recurrent oropharyngeal squamous cell carcinoma (OPSCC). Current data regarding types of surgery and the impact of surgery for patients with distant metastatic disease are limited.
METHODS
A retrospective analysis of patients with recurrent OPSCC from 2 institutions between 2000 and 2012 was performed. p16 immunohistochemistry and/or in situ hybridization, as clinically available, were used to determine HPV tumor status. Clinical characteristics, distribution of recurrence site, and treatment modalities were compared by HPV tumor status. Overall survival (OS) was examined using Kaplan‐Meier and Cox proportional hazards methods.
RESULTS
The current study included 108 patients with 65 locoregional and 43 distant metastatic first recurrences. The majority of …
学术搜索中的文章
T Guo, JR Qualliotine, PK Ha, JA Califano, Y Kim… - Cancer, 2015