作者
Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura, Yoshiaki Okamoto, Yoko Suzuki, Tetsuya Kawabe, Miki Saito, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, Kazuro Sugimura
发表日期
2010/5
期刊
Head & neck
卷号
32
期号
5
页码范围
646-655
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Background.
The aim of this study was to evaluate the significance of nuclear factor‐kappa B (NF‐κB) expression as a marker of radioresistance in early‐stage laryngeal cancer.
Methods.
Thirty‐five patients with local recurrence and 70 case‐matched patients without local recurrence were entered in this study. NF‐κB expression was compared with Bcl‐2 and epidermal growth factor (EGF) receptor expression by immunohistochemistry, using pretreatment biopsy specimens. The prognostic value of NF‐κB was also evaluated. Twenty‐nine recurrent tumors were compared with pretreatment tumors.
Results.
NF‐κB expression in pretreatment tumors significantly correlated with local tumor control (p = .01), but bcl‐2 and EGF receptor expression did not. Only NF‐κB expression showed prognostic significance for local tumor control in both univariate and multivariate analyses (p = .008 and .04, respectively). NF‐κB …
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K Yoshida, R Sasaki, H Nishimura, Y Okamoto… - Head & neck, 2010