作者
Annette Langer-Gould, Lei Qian, Sara Y Tartof, Sonu M Brara, Steve J Jacobsen, Brandon E Beaber, Lina S Sy, Chun Chao, Rulin Hechter, Hung Fu Tseng
发表日期
2014/12/1
期刊
JAMA neurology
卷号
71
期号
12
页码范围
1506-1513
出版商
American Medical Association
简介
Importance
Because vaccinations are common, even a small increased risk of multiple sclerosis (MS) or other acquired central nervous system demyelinating syndromes (CNS ADS) could have a significant effect on public health.
Objective
To determine whether vaccines, particularly those for hepatitis B (HepB) and human papillomavirus (HPV), increase the risk of MS or other CNS ADS.
Design, Setting, and Participants
A nested case-control study was conducted using data obtained from the complete electronic health records of Kaiser Permanente Southern California (KPSC) members. Cases were identified through the KPSC CNS ADS cohort between 2008 and 2011, which included extensive review of medical records by an MS specialist. Five controls per case were matched on age, sex, and zip code.
Exposures
Vaccination of any type (particularly HepB and HPV) identified through the electronic vaccination …
学术搜索中的文章
A Langer-Gould, L Qian, SY Tartof, SM Brara… - JAMA neurology, 2014
