作者
Karl H Tully, David-Dan Nguyen, Peter Herzog, Ginger Jin, Joachim Noldus, Paul L Nguyen, Adam S Kibel, Maxine Sun, Bradley McGregor, Shehzad Basaria, Quoc-Dien Trinh
发表日期
2021/2/1
期刊
European Urology Oncology
卷号
4
期号
1
页码范围
66-72
出版商
Elsevier
简介
Background
Previous studies have found an association between androgen deprivation therapy (ADT) and an increased risk of dementia and depression in elderly men. This association remains controversial, and little is known about the effects of ADT in younger men.
Objective
To examine the association between the receipt of ADT and these outcomes in young men aged 40–64 yr presenting with nonmetastatic prostate cancer (PCa).
Design, setting, and participants
For this observational study, we identified 9117 men aged 40–64 yr diagnosed with localized PCa between 2007 and 2014, without a pre-existing neurocognitive diagnosis, using the TRICARE military database.
Outcome measurements and statistical analysis
Kaplan-Meier curves were fitted to compare ADT versus no ADT. We also performed a subgroup analysis in patients undergoing ADT for ≥12 mo. The association between ADT and new-onset …
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KH Tully, DD Nguyen, P Herzog, G Jin, J Noldus… - European Urology Oncology, 2021