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A newly developed copper‐bearing stainless steel (Cu‐SS) by directly immobilizing proper amount of Cu into a medical stainless steel (317L SS) during the metallurgical process could enable continuous release of trace amount of Cu²⁺ ions, which play the key role to offer the multi‐biofunctions of the stainless steel, including the osteogenic ability in the present study. The results of in vitro experiments clearly demonstrated that Cu²⁺ ions from Cu‐SS could promote the osteogenic differentiation by stimulating the Alkaline phosphatase enzyme activity and the osteogenic gene expressions (Col1a1, Opn, and Runx2), and enhancing the adhesion and proliferation of osteoblasts cultured on its surface. The in vivo test further proved that more new bone tissue formed around the Cu‐SS implant with more stable bone‐to‐implant contact in comparison with the 317L SS. In addition, Cu‐SS showed satisfied …