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The present article is concerned with the slip effects on unsteady pulsatile blood flow through a curved channel containing nano-particles in the presence of stenosis and aneurysm. The nano-particles momentum and thermal energy equations are developed using curvilinear co-ordinates. The suitable slip boundary conditions are imposed at the channel walls. Employing mild stenotic condition, the governing differential equations are solved numerically using a robust explicit finite difference scheme. The effects of slip on various hemo-dynamical variables such as velocity, flow rate, wall shear stress and resistance to flow are shown through plots. The effects of nano-scale particles and thermo fluid parameters on flow and heat transfer characteristics of blood have been discussed in detail in this article. The flow patterns are also shown through plotting streamlines. Calculated results reveal that velocity, flow rate and …